Industrial Experience with Oxygen Control of a Fed-batch Filamentous Fungal Fermentation
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چکیده
Fed-batch filamentous fungal fermentations at the industrial level are operated today either in an open-loop manner or through simple PI control, both with limited performance. The main challenge presented by such an operation is that, due to the presence of uncertainties of the inoculum, the process can go into oxygen limitation that severely affects production. In this paper, a cascade control strategy for regulation of the dissolved oxygen is presented, which incorporates available auxiliary measurements to improve performance. This strategy is formulated based on the investigation of the structural elements of a simplified process model developed from experimental data. Experimental results confirm the efficiency of the proposed control strategy. Copyright c ©2005 IFAC
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تاریخ انتشار 2005